Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 13 Researches
7
USERS' SCORE
Good
Based on 5 Reviews
8.5
Supplement Facts
Serving Size: 1 Capsule
Amount Per Serving
%DV
Vitamin D3 (as cholecalciferol)
125 mcg
625%
Vitamin K activity from:Vitamin K1 (as phytonadione)Vitamin K2 (as menaquinone-4)Vitamin K2 (as trans menaquinone-7)
2,100 mcg1,000 mcg1,000 mcg100 mcg
1,750%
Iodine [from Sea-Iodine™ Complex Blend (organic kelp and bladderwrack extracts, potassium iodide)]
1,000 mcg
667%
Top Medical Research Studies
1
We conducted a thorough investigation into the effects of vitamin D3 supplementation on knee pain and cartilage volume in people suffering from knee osteoarthritis, particularly those with low vitamin D levels. This study took place in Tasmania and Victoria, Australia, and was designed as a multicenter, randomized, double-blind, placebo-controlled clinical trial.
Over a span of two years, we divided participants into two groups: one received a monthly dose of oral vitamin D3 (50,000 IU), while the other group received a placebo. Our main focus was to evaluate any changes in tibial cartilage volume, measured through MRI, as well as the participants' knee pain levels as indicated by the Western Ontario and McMaster Universities Arthritis Index (WOMAC) pain score.
The results showed that, compared to the placebo group, those who received vitamin D3 experienced no significant differences in either tibial cartilage volume or reported knee pain over the two years. This indicates that vitamin D3 supplementation does not provide meaningful benefits for reducing tibial cartilage loss or improving knee pain in patients with symptomatic knee osteoarthritis.
Over a span of two years, we divided participants into two groups: one received a monthly dose of oral vitamin D3 (50,000 IU), while the other group received a placebo. Our main focus was to evaluate any changes in tibial cartilage volume, measured through MRI, as well as the participants' knee pain levels as indicated by the Western Ontario and McMaster Universities Arthritis Index (WOMAC) pain score.
The results showed that, compared to the placebo group, those who received vitamin D3 experienced no significant differences in either tibial cartilage volume or reported knee pain over the two years. This indicates that vitamin D3 supplementation does not provide meaningful benefits for reducing tibial cartilage loss or improving knee pain in patients with symptomatic knee osteoarthritis.
1
Vitamin D3 ineffective for knee pain
We conducted a thorough investigation into whether vitamin D3 supplementation could alleviate knee pain in individuals with osteoarthritis. Our study involved 146 participants, all experiencing symptomatic knee osteoarthritis. They were either given a placebo or oral doses of vitamin D3, specifically aimed at achieving serum levels greater than 36 ng/mL over two years.
The main focus was on evaluating changes in knee pain and cartilage loss, utilizing the Western Ontario and McMaster Universities (WOMAC) pain scale for symptoms and magnetic resonance imaging for cartilage assessment. Unfortunately, our findings revealed that vitamin D supplementation did not lead to any significant reduction in knee pain or cartilage loss when compared to the placebo.
While we were hopeful that vitamin D3 might provide some relief, the results clearly indicated that this approach did not yield the desired effects in patients suffering from knee osteoarthritis. This outcome is crucial as it helps to shape future treatment approaches for this common condition.
The main focus was on evaluating changes in knee pain and cartilage loss, utilizing the Western Ontario and McMaster Universities (WOMAC) pain scale for symptoms and magnetic resonance imaging for cartilage assessment. Unfortunately, our findings revealed that vitamin D supplementation did not lead to any significant reduction in knee pain or cartilage loss when compared to the placebo.
While we were hopeful that vitamin D3 might provide some relief, the results clearly indicated that this approach did not yield the desired effects in patients suffering from knee osteoarthritis. This outcome is crucial as it helps to shape future treatment approaches for this common condition.
9
We aimed to understand the therapeutic impact of vitamin D3 on knee pain associated with osteoarthritis (OA). In a 3-month open-label clinical trial, we observed 80 patients with knee OA who took an oral supplement of vitamin D3 at a dosage of 4000 IU per day.
Over the course of the study, we measured the participants' pain levels and functionality using WOMAC subscores and Visual Analog Scale (VAS) assessments. Excitingly, we found that the average pain intensity decreased significantly after treatment. In fact, about 87% of the participants showed a notable positive response to the vitamin D3 supplementation.
Alongside improvements in pain, we also noted changes in certain inflammation markers in the blood. There was a significant decrease in pro-inflammatory cytokines like TNF-α and IL-17, while levels of IL-33 increased. This suggests that vitamin D3 might play a role in modulating the inflammatory processes related to knee OA.
Ultimately, our findings highlight the potential of vitamin D3 supplementation as a promising therapeutic option for managing knee OA symptoms. Further research is warranted to delve deeper into the role of IL-33 and its implications for osteoarthritis.
Over the course of the study, we measured the participants' pain levels and functionality using WOMAC subscores and Visual Analog Scale (VAS) assessments. Excitingly, we found that the average pain intensity decreased significantly after treatment. In fact, about 87% of the participants showed a notable positive response to the vitamin D3 supplementation.
Alongside improvements in pain, we also noted changes in certain inflammation markers in the blood. There was a significant decrease in pro-inflammatory cytokines like TNF-α and IL-17, while levels of IL-33 increased. This suggests that vitamin D3 might play a role in modulating the inflammatory processes related to knee OA.
Ultimately, our findings highlight the potential of vitamin D3 supplementation as a promising therapeutic option for managing knee OA symptoms. Further research is warranted to delve deeper into the role of IL-33 and its implications for osteoarthritis.
Most Useful Reviews
9
Remarkable improvement
12 people found this helpful
I cannot express how much I have benefited from this excellent product over two years. I searched for this formula of vitamin D, K2, and iodine and found it here. Since then, everything has improved greatly—my health, my sleep, my energy, and notably, my knees and bones. I wish I could give it more than a thousand stars as it has become essential in my life.
10
Injury recovery
Prescribed after a severe knee injury, this vitamin complex, alongside collagen and calcium, has greatly reduced my knee pain. Recommended for use twice a year.
9
Softens knees
1 people found this helpful
It aids in making my knees soft and improves the ease of bending.
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 13 Researches
7
- All Researches
9
We aimed to understand the therapeutic impact of vitamin D3 on knee pain associated with osteoarthritis (OA). In a 3-month open-label clinical trial, we observed 80 patients with knee OA who took an oral supplement of vitamin D3 at a dosage of 4000 IU per day.
Over the course of the study, we measured the participants' pain levels and functionality using WOMAC subscores and Visual Analog Scale (VAS) assessments. Excitingly, we found that the average pain intensity decreased significantly after treatment. In fact, about 87% of the participants showed a notable positive response to the vitamin D3 supplementation.
Alongside improvements in pain, we also noted changes in certain inflammation markers in the blood. There was a significant decrease in pro-inflammatory cytokines like TNF-α and IL-17, while levels of IL-33 increased. This suggests that vitamin D3 might play a role in modulating the inflammatory processes related to knee OA.
Ultimately, our findings highlight the potential of vitamin D3 supplementation as a promising therapeutic option for managing knee OA symptoms. Further research is warranted to delve deeper into the role of IL-33 and its implications for osteoarthritis.
Over the course of the study, we measured the participants' pain levels and functionality using WOMAC subscores and Visual Analog Scale (VAS) assessments. Excitingly, we found that the average pain intensity decreased significantly after treatment. In fact, about 87% of the participants showed a notable positive response to the vitamin D3 supplementation.
Alongside improvements in pain, we also noted changes in certain inflammation markers in the blood. There was a significant decrease in pro-inflammatory cytokines like TNF-α and IL-17, while levels of IL-33 increased. This suggests that vitamin D3 might play a role in modulating the inflammatory processes related to knee OA.
Ultimately, our findings highlight the potential of vitamin D3 supplementation as a promising therapeutic option for managing knee OA symptoms. Further research is warranted to delve deeper into the role of IL-33 and its implications for osteoarthritis.
9
We explored the effects of vitamin D (D3) on knee pain recovery after total knee arthroplasty (TKA). In our study, we enrolled 60 patients and categorized them into three groups based on their vitamin D levels. Some patients had sufficient vitamin D, while others were either given large doses of oral or intramuscular supplementation if they were found to be insufficient.
Our findings revealed that patients with insufficient vitamin D experienced significant improvements in their knee function after receiving large oral doses. In fact, those who received oral supplements showed recovery comparable to patients who already had sufficient vitamin D. Conversely, while intramuscular supplementation did increase vitamin D levels, it was less effective compared to the oral method and only showed noticeable improvement by the two-week mark.
Interestingly, we also noted that about 25% of patients who initially had sufficient vitamin D levels became insufficient within the first two weeks post-surgery. This indicates that even those with adequate levels may need to consider supplementation after undergoing TKA to maintain optimal recovery.
In summary, our study suggests that quickly addressing vitamin D deficiency with oral supplementation can play a crucial role in enhancing recovery and reducing knee pain following TKA.
Our findings revealed that patients with insufficient vitamin D experienced significant improvements in their knee function after receiving large oral doses. In fact, those who received oral supplements showed recovery comparable to patients who already had sufficient vitamin D. Conversely, while intramuscular supplementation did increase vitamin D levels, it was less effective compared to the oral method and only showed noticeable improvement by the two-week mark.
Interestingly, we also noted that about 25% of patients who initially had sufficient vitamin D levels became insufficient within the first two weeks post-surgery. This indicates that even those with adequate levels may need to consider supplementation after undergoing TKA to maintain optimal recovery.
In summary, our study suggests that quickly addressing vitamin D deficiency with oral supplementation can play a crucial role in enhancing recovery and reducing knee pain following TKA.
9
We aimed to understand how vitamin D3 supplementation influences knee pain and muscle strength in individuals suffering from knee osteoarthritis (KOA). The study involved 67 patients over the age of 30, all experiencing knee pain for at least a month and showing signs of vitamin D deficiency.
Participants received a weekly dose of 50,000 IU of oral cholecalciferol (vitamin D3) for a span of two months. By the end of the treatment, nearly all participants had sufficient levels of vitamin D. Significant improvements were observed; serum vitamin D levels rose, quadriceps muscle strength increased, and knee pain decreased for the majority of participants.
Specifically, the pain reduction was measurable through standard pain assessment methods. The findings suggest a clear link between correcting vitamin D deficiency and improvements in both muscle strength and pain levels for those living with KOA.
Participants received a weekly dose of 50,000 IU of oral cholecalciferol (vitamin D3) for a span of two months. By the end of the treatment, nearly all participants had sufficient levels of vitamin D. Significant improvements were observed; serum vitamin D levels rose, quadriceps muscle strength increased, and knee pain decreased for the majority of participants.
Specifically, the pain reduction was measurable through standard pain assessment methods. The findings suggest a clear link between correcting vitamin D deficiency and improvements in both muscle strength and pain levels for those living with KOA.
9
We examined the impact of vitamin D3 in a patient suffering from adult Fanconi syndrome, who experienced notable knee pain among other symptoms. This individual, a 42-year-old female, presented with various issues including progressive proximal muscle weakness and marked bone discomfort, particularly in the knees. After a thorough evaluation that included electromyography and a muscle biopsy, she was diagnosed with this rare condition, which often results in deficiencies that can lead to significant pain and discomfort.
Following a comprehensive treatment plan, which included tricalcium phosphate, vitamin D3, and sodium bicarbonate, we observed positive changes in her symptoms. The patient's knee pain, along with other discomforts, notably improved after a six-week supplementation regimen. However, it's essential to clarify that while vitamin D3 was part of a combined treatment, the specific contribution of vitamin D3 to alleviating knee pain is hard to isolate. We conclude that vitamin D3 may offer some benefits when included in a broader treatment framework, but further research would be needed to fully understand its role in managing knee pain specifically.
Following a comprehensive treatment plan, which included tricalcium phosphate, vitamin D3, and sodium bicarbonate, we observed positive changes in her symptoms. The patient's knee pain, along with other discomforts, notably improved after a six-week supplementation regimen. However, it's essential to clarify that while vitamin D3 was part of a combined treatment, the specific contribution of vitamin D3 to alleviating knee pain is hard to isolate. We conclude that vitamin D3 may offer some benefits when included in a broader treatment framework, but further research would be needed to fully understand its role in managing knee pain specifically.
8
We investigated the role of Vitamin D3 in managing post-operative knee pain after unicompartmental knee arthroplasty (UKA). Our study involved 240 patients divided into three groups based on their Vitamin D3 levels. One group had their deficiency corrected before surgery, another received treatment after the operation, and the last group had normal levels from the start.
We aimed to determine not only how Vitamin D3 levels affected post-operative pain but also the benefits of correcting any deficiencies pre-operatively. Our findings revealed that correcting Vitamin D3 levels before surgery significantly improved pain management for patients. Those who were treated pre-operatively experienced better control of post-operative pain compared to those whose deficiencies were addressed afterwards.
In summary, we found that Vitamin D3 is an essential component in pre-operative assessments for patients undergoing UKA. Addressing any deficiencies beforehand seems to lead to improved outcomes in pain relief, highlighting its importance as a modifiable risk factor in surgical recovery.
We aimed to determine not only how Vitamin D3 levels affected post-operative pain but also the benefits of correcting any deficiencies pre-operatively. Our findings revealed that correcting Vitamin D3 levels before surgery significantly improved pain management for patients. Those who were treated pre-operatively experienced better control of post-operative pain compared to those whose deficiencies were addressed afterwards.
In summary, we found that Vitamin D3 is an essential component in pre-operative assessments for patients undergoing UKA. Addressing any deficiencies beforehand seems to lead to improved outcomes in pain relief, highlighting its importance as a modifiable risk factor in surgical recovery.
User Reviews
USERS' SCORE
Good
Based on 5 Reviews
8.5
- All Reviews
- Positive Reviews
- Negative Reviews
9
Remarkable improvement
12 people found this helpful
I cannot express how much I have benefited from this excellent product over two years. I searched for this formula of vitamin D, K2, and iodine and found it here. Since then, everything has improved greatly—my health, my sleep, my energy, and notably, my knees and bones. I wish I could give it more than a thousand stars as it has become essential in my life.
10
Injury recovery
Prescribed after a severe knee injury, this vitamin complex, alongside collagen and calcium, has greatly reduced my knee pain. Recommended for use twice a year.
9
Softens knees
1 people found this helpful
It aids in making my knees soft and improves the ease of bending.
7.5
Pain reduction
The composition effectively prevents blood vessels from clogging and promotes calcium absorption, alongside benefits for the thyroid gland. There’s a noticeable improvement in my leg pain.
6
Crackling reduction
I’ve been taking this for three months due to crackling knees. While it hasn't completely stopped, the condition has significantly improved.
Frequently Asked Questions
6
Crackling reduction
I’ve been taking this for three months due to crackling knees. While it hasn't completely stopped, the condition has significantly improved.
10
Injury recovery
Prescribed after a severe knee injury, this vitamin complex, alongside collagen and calcium, has greatly reduced my knee pain. Recommended for use twice a year.
9
Remarkable improvement
12 people found this helpful
I cannot express how much I have benefited from this excellent product over two years. I searched for this formula of vitamin D, K2, and iodine and found it here. Since then, everything has improved greatly—my health, my sleep, my energy, and notably, my knees and bones. I wish I could give it more than a thousand stars as it has become essential in my life.
9
Softens knees
1 people found this helpful
It aids in making my knees soft and improves the ease of bending.
9
We aimed to understand the therapeutic impact of vitamin D3 on knee pain associated with osteoarthritis (OA). In a 3-month open-label clinical trial, we observed 80 patients with knee OA who took an oral supplement of vitamin D3 at a dosage of 4000 IU per day.
Over the course of the study, we measured the participants' pain levels and functionality using WOMAC subscores and Visual Analog Scale (VAS) assessments. Excitingly, we found that the average pain intensity decreased significantly after treatment. In fact, about 87% of the participants showed a notable positive response to the vitamin D3 supplementation.
Alongside improvements in pain, we also noted changes in certain inflammation markers in the blood. There was a significant decrease in pro-inflammatory cytokines like TNF-α and IL-17, while levels of IL-33 increased. This suggests that vitamin D3 might play a role in modulating the inflammatory processes related to knee OA.
Ultimately, our findings highlight the potential of vitamin D3 supplementation as a promising therapeutic option for managing knee OA symptoms. Further research is warranted to delve deeper into the role of IL-33 and its implications for osteoarthritis.
Over the course of the study, we measured the participants' pain levels and functionality using WOMAC subscores and Visual Analog Scale (VAS) assessments. Excitingly, we found that the average pain intensity decreased significantly after treatment. In fact, about 87% of the participants showed a notable positive response to the vitamin D3 supplementation.
Alongside improvements in pain, we also noted changes in certain inflammation markers in the blood. There was a significant decrease in pro-inflammatory cytokines like TNF-α and IL-17, while levels of IL-33 increased. This suggests that vitamin D3 might play a role in modulating the inflammatory processes related to knee OA.
Ultimately, our findings highlight the potential of vitamin D3 supplementation as a promising therapeutic option for managing knee OA symptoms. Further research is warranted to delve deeper into the role of IL-33 and its implications for osteoarthritis.
8
We conducted a thorough analysis of several randomized controlled trials to see how vitamin D3 affects knee pain, particularly in those suffering from osteoarthritis (OA). By examining data from four studies involving over 1,100 participants, we looked specifically at pain relief and functional improvement as measured by the Western Ontario and McMaster Universities Arthritis Index (WOMAC).
Our findings are quite revealing: while vitamin D3 significantly reduced pain and improved function for those with knee OA, it did not prevent cartilage loss in the knee joints. This is an important distinction, as many may assume pain relief could also equate to structural benefits.
Interestingly, vitamin D3 supplementation of more than 2,000 IU daily showed the most promise in terms of reducing pain and enhancing functionality. However, it's worth noting that the treatment did not increase the risk of adverse effects when compared to placebo groups.
Overall, while vitamin D3 may help alleviate knee pain and improve overall mobility, the evidence does not support its use in slowing down the progression of knee osteoarthritis itself. This indicates a need for further research to explore more comprehensive treatment options for those managing OA.
Our findings are quite revealing: while vitamin D3 significantly reduced pain and improved function for those with knee OA, it did not prevent cartilage loss in the knee joints. This is an important distinction, as many may assume pain relief could also equate to structural benefits.
Interestingly, vitamin D3 supplementation of more than 2,000 IU daily showed the most promise in terms of reducing pain and enhancing functionality. However, it's worth noting that the treatment did not increase the risk of adverse effects when compared to placebo groups.
Overall, while vitamin D3 may help alleviate knee pain and improve overall mobility, the evidence does not support its use in slowing down the progression of knee osteoarthritis itself. This indicates a need for further research to explore more comprehensive treatment options for those managing OA.
8
We investigated the role of Vitamin D3 in managing post-operative knee pain after unicompartmental knee arthroplasty (UKA). Our study involved 240 patients divided into three groups based on their Vitamin D3 levels. One group had their deficiency corrected before surgery, another received treatment after the operation, and the last group had normal levels from the start.
We aimed to determine not only how Vitamin D3 levels affected post-operative pain but also the benefits of correcting any deficiencies pre-operatively. Our findings revealed that correcting Vitamin D3 levels before surgery significantly improved pain management for patients. Those who were treated pre-operatively experienced better control of post-operative pain compared to those whose deficiencies were addressed afterwards.
In summary, we found that Vitamin D3 is an essential component in pre-operative assessments for patients undergoing UKA. Addressing any deficiencies beforehand seems to lead to improved outcomes in pain relief, highlighting its importance as a modifiable risk factor in surgical recovery.
We aimed to determine not only how Vitamin D3 levels affected post-operative pain but also the benefits of correcting any deficiencies pre-operatively. Our findings revealed that correcting Vitamin D3 levels before surgery significantly improved pain management for patients. Those who were treated pre-operatively experienced better control of post-operative pain compared to those whose deficiencies were addressed afterwards.
In summary, we found that Vitamin D3 is an essential component in pre-operative assessments for patients undergoing UKA. Addressing any deficiencies beforehand seems to lead to improved outcomes in pain relief, highlighting its importance as a modifiable risk factor in surgical recovery.
1
We conducted a thorough investigation into the effects of vitamin D3 supplementation on knee pain and cartilage volume in people suffering from knee osteoarthritis, particularly those with low vitamin D levels. This study took place in Tasmania and Victoria, Australia, and was designed as a multicenter, randomized, double-blind, placebo-controlled clinical trial.
Over a span of two years, we divided participants into two groups: one received a monthly dose of oral vitamin D3 (50,000 IU), while the other group received a placebo. Our main focus was to evaluate any changes in tibial cartilage volume, measured through MRI, as well as the participants' knee pain levels as indicated by the Western Ontario and McMaster Universities Arthritis Index (WOMAC) pain score.
The results showed that, compared to the placebo group, those who received vitamin D3 experienced no significant differences in either tibial cartilage volume or reported knee pain over the two years. This indicates that vitamin D3 supplementation does not provide meaningful benefits for reducing tibial cartilage loss or improving knee pain in patients with symptomatic knee osteoarthritis.
Over a span of two years, we divided participants into two groups: one received a monthly dose of oral vitamin D3 (50,000 IU), while the other group received a placebo. Our main focus was to evaluate any changes in tibial cartilage volume, measured through MRI, as well as the participants' knee pain levels as indicated by the Western Ontario and McMaster Universities Arthritis Index (WOMAC) pain score.
The results showed that, compared to the placebo group, those who received vitamin D3 experienced no significant differences in either tibial cartilage volume or reported knee pain over the two years. This indicates that vitamin D3 supplementation does not provide meaningful benefits for reducing tibial cartilage loss or improving knee pain in patients with symptomatic knee osteoarthritis.
9
We aimed to understand how vitamin D3 supplementation influences knee pain and muscle strength in individuals suffering from knee osteoarthritis (KOA). The study involved 67 patients over the age of 30, all experiencing knee pain for at least a month and showing signs of vitamin D deficiency.
Participants received a weekly dose of 50,000 IU of oral cholecalciferol (vitamin D3) for a span of two months. By the end of the treatment, nearly all participants had sufficient levels of vitamin D. Significant improvements were observed; serum vitamin D levels rose, quadriceps muscle strength increased, and knee pain decreased for the majority of participants.
Specifically, the pain reduction was measurable through standard pain assessment methods. The findings suggest a clear link between correcting vitamin D deficiency and improvements in both muscle strength and pain levels for those living with KOA.
Participants received a weekly dose of 50,000 IU of oral cholecalciferol (vitamin D3) for a span of two months. By the end of the treatment, nearly all participants had sufficient levels of vitamin D. Significant improvements were observed; serum vitamin D levels rose, quadriceps muscle strength increased, and knee pain decreased for the majority of participants.
Specifically, the pain reduction was measurable through standard pain assessment methods. The findings suggest a clear link between correcting vitamin D deficiency and improvements in both muscle strength and pain levels for those living with KOA.
References
- Rajani AM, Mittal A, Kulkarni VU, Rajani KA, Rajani KA. Role of Pre-operative Correction of Vitamin D3 Deficiency in Controlling Post-operative Bone Pain after Unicompartmental Knee Arthroplasty. Malays Orthop J. 2024;18:7. doi:10.5704/MOJ.2411.002
- Qi L, Guo Y. Fibrodysplasia Ossificans Progressiva: A Case Report. Cureus. 2024;16:e55528. doi:10.7759/cureus.55528
- Divjak A, Jovanovic I, Matic A, Lucic AT, Gajovic N, et al. The influence of vitamin D supplementation on the expression of mediators of inflammation in knee osteoarthritis. Immunol Res. 2023;71:442. doi:10.1007/s12026-022-09354-0
- Peng HM, Weng XS, Li Y, Feng B, Qian W, et al. Effect of alendronate sodium plus vitamin D tablets on knee joint structure and osteoarthritis pain: a multi-center, randomized, double-blind, placebo-controlled study protocol. BMC Musculoskelet Disord. 2022;23:584. doi:10.1186/s12891-022-05521-4
- Maniar RN, Maniar AR, Jain D, Bhatnagar N, Gajjar A. Vitamin D Trajectory after Total Knee Arthroplasty: A Method for Quick Correction in Deficient Patients. Clin Orthop Surg. 2021;13:336. doi:10.4055/cios20147
- Tu L, Zheng S, Cicuttini F, Jin X, Han W, et al. Effects of Vitamin D Supplementation on Disabling Foot Pain in Patients With Symptomatic Knee Osteoarthritis. Arthritis Care Res (Hoboken). 2021;73:781. doi:10.1002/acr.24371
- Gao XR, Chen YS, Deng W. The effect of vitamin D supplementation on knee osteoarthritis: A meta-analysis of randomized controlled trials. Int J Surg. 2017;46:14. doi:10.1016/j.ijsu.2017.08.010
- Xu C, Ma C, Bai Y. A pediatric hypophosphatemic rickets on MRI, Tc-MDP bone scan and F-FDG PET/CT. Hell J Nucl Med. 2017;20:93. doi:10.1967/s002449910515
- Jin X, Jones G, Cicuttini F, Wluka A, Zhu Z, et al. Effect of Vitamin D Supplementation on Tibial Cartilage Volume and Knee Pain Among Patients With Symptomatic Knee Osteoarthritis: A Randomized Clinical Trial. JAMA. 2016;315:1005. doi:10.1001/jama.2016.1961
- Heidari B, Javadian Y, Babaei M, Yousef-Ghahari B. Restorative Effect of Vitamin D Deficiency on Knee Pain and Quadriceps Muscle Strength in Knee Osteoarthritis. Acta Med Iran. 2015;53:466.
- McAlindon T, LaValley M, Schneider E, Nuite M, Lee JY, et al. Effect of vitamin D supplementation on progression of knee pain and cartilage volume loss in patients with symptomatic osteoarthritis: a randomized controlled trial. JAMA. 2013;309:155. doi:10.1001/jama.2012.164487
- Cao Y, Jones G, Cicuttini F, Winzenberg T, Wluka A, et al. Vitamin D supplementation in the management of knee osteoarthritis: study protocol for a randomized controlled trial. Trials. 2012;13:131. doi:10.1186/1745-6215-13-131
- Lian LM, Chang YC, Yang CC, Yang JC, Kao KP, et al. Adult Fanconi syndrome with proximal muscle weakness and hypophosphatemic osteomalacia: report of a case. J Formos Med Assoc. 1994;93:709.
